|
KMID : 1161420170200090855
|
|
Journal of Medicinal Food
2017 Volume.20 No. 9 p.855 ~ p.863
|
|
|
γ-Oryzanol-Rich Black Rice Bran Extract Enhances the Innate Immune Response
|
|
Shin Soon-Young
Kim Heon-Woong
Jang Hwan-Hee
Hwang Yu-Jin
Choe Jeong-Sook
Lim Yoong-Ho
Kim Jung-Bong
Lee Young-Han
|
|
|
Abstract
|
|
|
|
The innate immune response is an important host primary defense system against pathogens. γ-Oryzanol is one of the nutritionally important phytoceutical components in rice bran oil. The goal of this study was to investigate the effect of γ-oryzanol-rich extract from black rice bran (γORE) on the activation of the innate immune system. In this study, we show that γORE increased the expression of CD14 and Toll-like receptor 4 and enhanced the phagocytic activity of RAW264.7 macrophages. Furthermore, γORE and its active ingredient γ-oryzanol promoted the secretion of innate cytokines, interleukin-8, and CCL2, which facilitate phagocytosis by RAW264.7 cells. These findings suggest that γ-oryzanol in the γORE enhances innate immune responses.
|
|
|
KEYWORD
|
|
|
black rice bran, γ-oryzanol, innate immune response, innate cytokine, phagocytosis, toll-like receptor 4
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|